Nanotheranostics - A review of recent publications
Journal
International Journal of Nanomedicine
Journal Volume
7
Pages
4679-4695
Date Issued
2012
Author(s)
Abstract
Theranostics is referred to as a treatment strategy that combines therapeutics with diagnostics, aiming to monitor the response to treatment and increase drug efficacy and safety, which would be a key part of personalized medicine and require considerable advances in predictive medicine. Theranostics associates with both a diagnosis that tests patients for possible reactions to taking new medication and targeted drug delivery based on the test results. Emerging nanotechnology provides a great deal of opportunity to design and develop such combination agents, permitting the delivery of therapeutics and concurrently allowing the detection modality to be used not only before or after but also throughout the entire treatment regimen. The introduction of nanotheranostics into routine health care has still a long way to go, since evaluations on cytotoxicity, genotoxicity, and immunotoxicity of prospective nanotheranostics, demonstration of cost-effectiveness, and availability of appropriate accessible testing systems are still required. An extensive review, from a chemistry point of view, of the recent development of nanotheranostics and its in vitro and in vivo applications are herein presented. ? 2012 Wang et al, publisher and licensee Dove Medical Press Ltd.
Subjects
Diagnostics; Nanomaterial; Theranostics; Therapeutics
SDGs
Other Subjects
carbon nanotube; chitosan; doxorubicin; gold nanoparticle; hyaluronic acid; magnetic nanoparticle; nanocarrier; nanocomposite; nanomaterial; polyglactin; polymer; silicon; biocompatibility; composite material; diagnostic imaging; drug coating; drug conjugation; drug delivery system; drug formulation; drug targeting; human; material state; molecular imaging; nanoemulsion; nanoencapsulation; nanofabrication; nanomedicine; nanoprobe; nanotherasnostic; nonhuman; nuclear magnetic resonance imaging; particle size; review; Contrast Media; Molecular Imaging; Nanomedicine; Nanostructures
Type
journal article