A wireless Bio-MEMS sensor for C-reactive protein detection based on nanomechanics
Journal
IEEE Transactions on Biomedical Engineering
Journal Volume
56
Journal Issue
2
Pages
462-470
Date Issued
2009
Author(s)
Chen, Chun-Hao
Nai-Kuan Chou
Huang, Long-Sun
Lin, Shi-Ming
Chen, Hsiao-Chin
Yang, Yu-Che
Lin, Yu-Tso
Yu, Shih-An
Wang, Yiao-Hong
Chou, Nai-Kuan
Abstract
A quick wireless label-free detection of disease-related C-reactive proteins (CRPs) using a 200- \mum-long microelectromechanical systems (MEMS) microcantilever housed in a \hbox{7} \times \hbox{7}\ \hbox{mm}^{2} reaction chamber with a safe reusable feature is reported. The assay time ranges from about 30 min to 3 h, depending on accuracy. The deflection of the microcantilever due to specific CRPantiCRP binding is detected using a position-sensitive detector. The converted bio-signal is transmitted by a custom designed wireless amplitude-shift-keying (ASK) transceiver IC fabricated in a 0.18 mu m CMOS process. CRP concentrations from 1 mug/mL to 500 mug/mL can be detected. A 0.2-Hz 1-V ac signal instead of traditional bases/acids is applied to the bio-MEMS sensor to unbind the CRP from the microcantilever for reusability. ? 2006 IEEE.
Other Subjects
Amplitude-shift-keying (ASK) receiver; Analog-to-digital converter (ADC); AntiCRP; ASK transmitter; C-reactive protein (CRP); Label-free; Microcantilever; Microcontrol unit (MCU); Poly-dimethyl-siloxane (PDMS); Atomic force microscopy; Composite micromechanics; Electromechanical devices; Frequency converters; Labels; Microchannels; Microsensors; Multicarrier modulation; Reusability; Silicones; Transmitters; MEMS; C reactive protein; dimeticone; amplitude modulation; analog digital converter; article; human; mathematical analysis; microelectromechanical system; molecular mechanics; process monitoring; protein analysis; protein binding; wireless communication; Biosensing Techniques; C-Reactive Protein; Cardiovascular Diseases; Dimethylpolysiloxanes; Equipment Design; Equipment Reuse; Humans; Micro-Electrical-Mechanical Systems; Monitoring, Ambulatory; Nanotechnology; Signal Processing, Computer-Assisted
Type
journal article