Group B streptococcus infection in infancy: 21-Year experience
Journal
Acta Paediatrica Taiwanica
Journal Volume
43
Journal Issue
6
Pages
326-329
Date Issued
2002
Author(s)
Abstract
In this hospital-based review, clinical presentations associated with Group B streptococcus (GBS) infections in children occurring between January 1980 and March 2000 were analyzed. Among the 25 infants with invasive group B streptococcal infections, 9 (36%) were early onset diseases (EOD), 12 (48%) were late onset diseases (LOD), and 4 (16%) occurred beyond the third month of life. Eight of the nine (89%) EOD cases manifested during the first day of life and three (33%) were premature births. Common presentations in GBS infection were fever (75%), poor activity (25%), respiratory distress (25%), lethargy (20%), and irritability (20%). Seizure occurred in 31% of infants with meningitis. Pneumonia (66%) and case-fatality rate (33.3%) were significantly higher in EOD than in LOD. Meningitis was the major manifestation (77%) of LOD and had severe sequelae in 40% of cases. Eight strains were assayed for antibiotic sensitivity and they were all susceptible to penicillin, ampicillin, cefotaxime, and vancomycin. The susceptibilities to erythromycin and clindamycin were 62% and 75%, respectively. Most of the strains from blood or cerebrospinal fluid were type III.
SDGs
Other Subjects
ampicillin; cefotaxime; clindamycin; erythromycin; penicillin G; vancomycin; adolescent; antibiotic sensitivity; article; bacterial strain; cerebrospinal fluid cytology; child; clinical article; clinical feature; controlled study; fever; follow up; high risk population; human; infant; infection rate; infection risk; irritability; lethargy; meningitis; onset age; physical activity; pneumonia; prematurity; respiratory distress; seizure; strain difference; Streptococcus agalactiae; Streptococcus infection; survival rate; Humans; Infant; Infant, Newborn; Retrospective Studies; Streptococcal Infections; Streptococcus agalactiae
Type
journal article