Brachial artery flow-mediated vasodilation in patients with cardiac syndrome X
Journal
Angiology
Journal Volume
59
Journal Issue
5
Pages
581-586
Date Issued
2008
Author(s)
Abstract
Cardiac syndrome X (CSX) differs from coronary artery disease (CAD) and is characterized by angina, positive stress test, and patent coronary arteries. The probable mechanism is a microvascular disorder associated with endothelial dysfunction. In this study, brachial artery flow-mediated vasodilation was used as well as the endothelin-1 assay to assess endothelial function in patients with cardiac syndrome X (CSX), coronary artery disease (CAD), and healthy controls. All subjects underwent a 2-step brachial artery flow-related vasodilatation test. Serum endothelin-1, one of the most potent constricting factors, was measured for all participants. Patients with CSX had a lower brachial artery dilation ratio than controls but higher than that of CAD patients. Control subjects and CSX patients had higher endothelin-1 levels than CAD patients. CSX patients were found to have worse endothelial function than healthy volunteers, but patients with CAD had even worse endothelium function than CSX patients. ? 2008 SAGE Publications.
Subjects
Cardiac syndrome X; Endothelin-1; Endothelium; Flow-mediated vasodilatation
SDGs
Other Subjects
endothelin 1; adult; aged; artery blood flow; article; brachial artery; cardiac syndrome X; clinical article; controlled study; coronary artery disease; female; heart disease; human; male; protein blood level; vasodilatation; Aged; Brachial Artery; Case-Control Studies; Coronary Artery Disease; Endothelin-1; Endothelium, Vascular; Female; Humans; Male; Microvascular Angina; Middle Aged; Regional Blood Flow; Vasodilation
Type
journal article