Polyurethane Nanoparticle-Loaded Fenofibrate Exerts Inhibitory Effects on Nonalcoholic Fatty Liver Disease in Mice
Journal
Molecular Pharmaceutics
Journal Volume
15
Journal Issue
10
Pages
4550-4557
Date Issued
2018
Author(s)
Abstract
Polyurethane (PU) nanoparticles are potential drug carriers. We aimed to study the in vitro and in vivo efficacy of biodegradable PU nanoparticles loaded with fenofibrate (FNB-PU) on nonalcoholic fatty liver disease (NAFLD). FNB-PU was prepared by a green process, and its preventive effects on NAFLD were investigated on HepG2 cells and mice. FNB-PU showed sustained in vitro FNB release profile. Compared to FNB crude drug, FNB-PU significantly decreased triglyceride content in HepG2 cells incubated with oleic acid and in livers of mice with NAFLD induced by a methionine choline deficient diet, and increased plasma FNB concentration of the mice. FNB-PU increased absorption of FNB and therefore enhanced the inhibitory effects of FNB on NAFLD. ? 2018 American Chemical Society.
Subjects
absorption enhancement; fenofibrate; inhibitory effects; nanoparticles; nonalcoholic fatty liver disease; polyurethane
SDGs
Other Subjects
fenofibrate; nanoparticle; oleic acid; polyurethan; triacylglycerol; antilipemic agent; drug carrier; fenofibrate; methionine; nanoparticle; polyurethan; animal experiment; animal model; animal tissue; Article; controlled study; drug absorption; drug blood level; drug efficacy; drug release; Hep-G2 cell line; human; human cell; in vitro study; in vivo study; male; methionine/choline deficient diet; mouse; nonalcoholic fatty liver; nonhuman; oral absorption; physical chemistry; priority journal; zeta potential; animal; C57BL mouse; chemistry; drug effect; liver; metabolism; nonalcoholic fatty liver; Animals; Drug Carriers; Fenofibrate; Hep G2 Cells; Humans; Hypolipidemic Agents; Liver; Male; Methionine; Mice; Mice, Inbred C57BL; Nanoparticles; Non-alcoholic Fatty Liver Disease; Polyurethanes
Type
journal article