MS-920: DNA REPAIR GENE POLYMORPHISMS, DIET AND COLORECTAL CANCER RISK IN TAIWAN
Resource
CANCER LETTERS v.224 n.2 pp.279-288
Journal
CANCER LETTERS
Journal Volume
v.224
Journal Issue
n.2
Pages
279-288
Date Issued
2005
Date
2005
Author(s)
SUNG, FUNG-CHANG
CHANG-CHIEH, CHUNG-RONG
TANG, REI-PING
HSIEH, LING-LING
YEH, CHIH-CHING
Abstract
This hospital-based case–control study examined whether polymorphic DNA repair genes: XRCC1 Arg399Gln, XRCC3 Thr241 Met and XPD Lys751Gln, play a role in the susceptibility to colorectal cancer. We genotyped these polymorphisms for 727 newly diagnosed colorectal adenocarcinoma cases and 736 age and sex matched healthy controls in Taiwan. Although the colorectal cancer risk was not significantly associated with these genes, the risk was significantly elevated in younger subjects (<=60 years) with the XRCC1 399Arg/Arg genotype compared to those with XRCC1 399Gln allele (OR=1.46, 95% CI= 1.06–2.99, P=0.02). The stratified analysis showed that XRCC3 interacted with meat consumption (P for interaction=0. 02), but was limited to the low meat consumption (OR=2.34, 95% CI=1.28–4.29). Our results suggest that the XRCC1 Arg 399Gln polymorphism may contribute to the risk of early- onset colorectal cancer and the XRCC3 Thr241Met polymorphism may modify the risk for meat- associated colorectal cancer.
Subjects
Colorectal cancer
XRCC1
XRCC3
XPD
Polymorphisms
Diet
SDGs
Type
journal article