Clinical Evaluation of Feline Polycystic Kidney Disease
Date Issued
2010
Date
2010
Author(s)
Wu, Tsai-Jung
Abstract
Polycystic kidney disease (PKD) is one of the most common inherited diseases in human, which is mostly autosomal dominant inherited and characterized by numbers of cysts occurred in renal parenchyma and results in end stage renal disease. In cats, the autosomal dominant PKD (ADPKD) is common in Persian cats and its out-crossed breeds, and could also be found in others breeds occasionally. Feline ADPKD shares many morphologic and pathogenetic features with ADPKD in human patients, and often results in renal failure at the end of disease. Diagnosis of PKD has primarily relied on renal ultrasonography, and a newly developed molecular method has been used to detect the mutated gene, PKD1 .This thesis includes two studies, the prevalence of polycystic kidney disease in cats in Taipei city and comparison of ultrasonographic findings and PCR result, and evaluation of systolic blood pressure and serum creatinine concentration in cats with and without polycystic kidney disease. Results of the first study revealed the prevalence of 23.3% in PKD in Persian and Persian related breeds and 12.0% in overall cats. The agreement between ultrasonography and PCR results was almost perfect (κ=0.84) in Persian and Persian related cats but slight in other breeds (κ=0), indicating PCR might only available in Persians, and ultrasonography might be a preferable method for diagnosis of PKD. Results of the second study revealed no significant correlation between PKD and systolic blood pressure or hypertension, although hypertension is a common complication in human patients with PKD. Furthermore, age (P=0.01) was the only factor affecting blood pressure in this study, and older cats tended to have higher blood pressure.
Subjects
Feline
polycystic kidney disease
ultrasonography
PCR
blood pressure
SDGs
Type
thesis
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