Usefulness of F-18-Fluorodeoxyglucose Positron Emission Tomography to Detect Para-Aortic Lymph Nodal Metastasis in Advanced Cervical Cancer with Negative Computed Tomography Findings
Resource
GYNECOLOGIC ONCOLOGY v.89 n.1 pp.73-76
Journal
GYNECOLOGIC ONCOLOGY
Journal Volume
v.89
Journal Issue
n.1
Pages
73-76
Date Issued
2003
Date
2003
Author(s)
YEN, RUOH-FANG
Abstract
Objective. In advanced cervical cancer, it has been reported that progression-free survival is significantly related to para-aortic lymph node metastasis. Computed tomography (CT) has been widely used for clinical staging, but its sensitivity for lymph nodal metastasis is low. Therefore, this prospective study was undertaken to evaluate F-18- fluorodeoxyglucose positron emission tomography (FDG-PET) in detecting para-aortic lymph nodal metastasis in patients with locally advanced cervical carcinoma when CT findings were negative. Methods. Fifty women with advanced cervical cancer confined to the pelvis with negative abdominal CT findings were included in this study. After 10 mCi of FDG was administered intravenously, the abdomens were scanned by PET. Para-aortic lymph node metastases were diagnosed as present or absent according to a standardized staging procedure. Results. Retroperitoneal surgical exploration revealed 14 patients with para-aortic lymph nodal metastasis . Two patients had false-negative FDG-PET findings and the other two patients had false-positive FDG-PET findings. Conclusion. Overall, FDG-PET imaging had a sensitivity of 85 .7%, a specificity of 94.4%, and an accuracy of 92%. When abdominal CT findings are negative, the use of FDG- PET can accurately detect para-aortic lymph nodal metastatis in patients with advanced cervical cancer. (C) 2003 Elsevier Science (USA). All rights reserved.
Subjects
F-18-fluorodeoxyglucose
positron emission tomography
para- aortic lymph nodal metastasis
advanced cervical cancer
SDGs