Thymoma-associated multiorgan autoimmunity
Journal
BMJ Case Reports
Journal Volume
12
Journal Issue
8
Pages
e229163
Date Issued
2019
Author(s)
Abstract
Thymoma-associated multiorgan autoimmunity is a relatively new term to describe the rare paraneoplastic syndrome that complicates thymoma, which can involve the thyroid, liver and intestine in addition to the skin. The pathology often indicates a graft-versus-host-like pattern commonly observed in recipients of an allogeneic haematopoietic cell transplant. We report a case of type B2 and B3 thymoma with invasion to the lung and pleura in a patient who presented with oral lichen planus and graft-versus-host-like erythroderma. The cutaneous lesions improved after complete resection of the thymoma in combination with systemic glucocorticoids, which was subsequently complicated by cytomegalovirus pneumonitis. ? BMJ Publishing Group Limited 2019.
SDGs
Other Subjects
azathioprine; methylprednisolone; prednisolone; vancomycin; glucocorticoid; adult; Article; autoimmune thyroiditis; autoimmunity; body weight loss; case report; cellulitis; clinical article; differential diagnosis; erythroderma; follow up; graft versus host like erythroderma; human; human tissue; lichen planus; male; mediastinum tumor; middle aged; outcome assessment; physical examination; pleura effusion; pleura metastasis; pleurectomy; pneumonia; priority journal; sternotomy; thoracotomy; thorax radiography; thymectomy; thymoma; autoimmune disease; complication; diagnostic imaging; image guided biopsy; lichen planus; lung; multimodality cancer therapy; pathology; pleura; thymoma; tumor invasion; Autoimmune Diseases; Combined Modality Therapy; Glucocorticoids; Humans; Image-Guided Biopsy; Lichen Planus, Oral; Lung; Male; Middle Aged; Neoplasm Invasiveness; Pleura; Thymoma; Thymus Neoplasms
Publisher
BMJ Publishing Group
Type
journal article