The application of nanogenerators and piezoelectricity in osteogenesis
Journal
Science and technology of advanced materials
Journal Volume
20
Journal Issue
1
Pages
1103
Date Issued
2019
Author(s)
Abstract
Bone is a complex organ possessing both physicomechanical and bioelectrochemical properties. In the view of Wolff's Law, bone can respond to mechanical loading and is subsequently reinforced in the areas of stress. Piezoelectricity is one of several mechanical responses of the bone matrix that allows osteocytes, osteoblasts, osteoclasts, and osteoprogenitors to react to changes in their environment. The present review details how osteocytes convert external mechanical stimuli into internal bioelectrical signals and the induction of intercellular cytokines from the standpoint of piezoelectricity. In addition, this review introduces piezoelectric and triboelectric materials used as self-powered electrical generators to promote osteogenic proliferation and differentiation due to their electromechanical properties, which could promote the development of promising applications in tissue engineering and bone regeneration.
Subjects
102 Porous / Nanoporous / Nanostructured materials; 202 Dielectrics / Piezoelectrics / Insulators; Osteogenesis; bone remodeling; nanogenerator; piezoelectricity
Publisher
TAYLOR & FRANCIS LTD
Type
review