Typhoid fever and typhoid hepatitis in Taiwan
Journal
Epidemiology and Infection
Journal Volume
133
Journal Issue
6
Pages
1073-1079
Date Issued
2005
Author(s)
Abstract
The annual incidence of typhoid fever in Taiwan was 2·1-3·6 cases per 1 000 000 population from 1995 to 2002. More than 80% of 45 patients with typhoid fever treated at National Taiwan University Hospital from 1996 to 2002 had elevated serum aminotransferase levels at presentation. Ten of these patients were treated during an outbreak in Taipei County in 2002, and seven of them who did not have pre-existing liver disease developed hepatitis, which was unrelated to other aetiologies. All Salmonella typhi isolates were susceptible to extended- spectrum cephalosporins and fluoroquinolones. Multidrug resistance (intermediate resistance to ampicillin, trimethoprim-sulphamethoxazole, and chloramphenicol) was found in one (2·5%) of the 40 isolates studied. Pulsed-field gel electrophoresis analysis demonstrated a high genetic diversity among S. typhi isolates and identified a novel clone associated with the 2002 outbreak. Physicians should be alert to the possibility of typhoid fever when patients, without other gastrointestinal symptoms, present with sustained fever and hepatitis. ? 2005 Cambridge University Press.
SDGs
Other Subjects
alanine aminotransferase; alkaline phosphatase; ampicillin; aspartate aminotransferase; aztreonam; bilirubin; C reactive protein; cefepime; cefotaxime; cefpirome; ceftriaxone; cephalosporin; chloramphenicol; ciprofloxacin; cotrimoxazole; hepatitis B core antibody; hepatitis B surface antigen; imipenem; immunoglobulin M; immunoglobulin M antibody; levofloxacin; moxifloxacin; quinolone derivative; virus antibody; virus RNA; adolescent; adult; aged; alanine aminotransferase blood level; antibiotic sensitivity; article; aspartate aminotransferase blood level; bacterium detection; bacterium identification; bacterium isolation; blood analysis; child; clinical article; clinical feature; correlation analysis; feces analysis; female; genetic variability; hepatitis C; Hepatitis C virus; human; incidence; infection sensitivity; male; minimum inhibitory concentration; molecular cloning; multidrug resistance; nonhuman; population research; pulsed field gel electrophoresis; Salmonella typhi; Taiwan; typhoid fever; university hospital; Anti-Bacterial Agents; Disease Outbreaks; Drug Resistance, Microbial; Hepatitis; Humans; Salmonella typhi; Taiwan; Typhoid Fever
Type
journal article