Interplay between Superoxide Dismutase, Glutathione Peroxidase, and Peroxisome Proliferator Activated Receptor Gamma Polymorphisms on the Risk of End-Stage Renal Disease among Han Chinese Patients
Journal
Oxidative Medicine and Cellular Longevity
Journal Volume
2016
Pages
8516748
Date Issued
2016
Author(s)
Abstract
Background. Single nucleotide polymorphisms (SNPs) of antioxidants, including superoxide dismutase 2 (SOD2) and glutathione peroxidase 1 (GPX1), play an important role in the risk for cancer and metabolic disorders. However, little is known regarding the effect of antioxidant SNPs on renal events. Methods. We prospectively enrolled multicenter patients with end-stage renal disease (ESRD) and those without chronic kidney disease (CKD) of Han Chinese origin, with SOD2 (Val16Ala), GPX1 (Pro197Leu), and PPAR-γ (Pro12Ala, C161T) genotyped. Multiple regression analyses were conducted to evaluate the significant risk determinants for ESRD. Results. Compared to ESRD patients, non-CKD subjects were more likely to have T allele at SOD2 Val16Ala (p = 0. 036) and CC genotype at PPAR-γ Pro12Ala (p = 0. 028). Regression analysis showed that TT genotype of SOD2 Val16Ala conferred significantly lower ESRD risk among patients without diabetes (odds ratio 0. 699; p = 0. 018). GPX1 SNP alone did not alter the risk. We detected significant interactions between SNPs including PPAR-γ Pro12Ala, C161T, and GPX1 regarding the risk of ESRD. Conclusion. This is the first and largest study on the association between adverse renal outcomes and antioxidant SNPs among Han Chinese population. Determination of SOD2 and PPAR-γ SNPs status might assist in ESRD risk estimation. ? 2016 Chia-Ter Chao et al.
SDGs
Other Subjects
Antioxidants; Cytology; Diseases; Enzymes; Oxygen; Peptides; Regression analysis; Risk perception; Chronic kidney disease; End stage renal disease; Glutathione peroxidase; Multiple regression analysis; Peroxisome proliferator-activated receptor; Single nucleotide polymorphisms; Super oxide dismutase; Superoxide dismutase 2; Risk assessment; glutathione peroxidase; manganese superoxide dismutase; peroxisome proliferator activated receptor gamma; glutathione peroxidase; glutathione peroxidase 1; manganese superoxide dismutase; peroxisome proliferator activated receptor gamma; superoxide dismutase; adult; aged; Article; chronic kidney disease; cohort analysis; diabetes mellitus; end stage renal disease; female; gene frequency; genetic association; genotype; Han Chinese; human; major clinical study; male; middle aged; multicenter study; prospective study; risk factor; single nucleotide polymorphism; Asian continental ancestry group; chronic kidney failure; clinical trial; enzymology; ethnic group; genetic predisposition; genetics; multivariate analysis; polymerase chain reaction; restriction fragment length polymorphism; single nucleotide polymorphism; statistical model; Asian Continental Ancestry Group; Cohort Studies; Ethnic Groups; Female; Gene Frequency; Genetic Predisposition to Disease; Glutathione Peroxidase; Humans; Kidney Failure, Chronic; Logistic Models; Male; Middle Aged; Multivariate Analysis; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; PPAR gamma; Risk Factors; Superoxide Dismutase
Type
journal article