Endoplasmic reticulum stress and type 2 diabetes mellitus
Journal
Journal of Internal Medicine of Taiwan
Journal Volume
17
Journal Issue
5
Pages
204-211
Date Issued
2006
Author(s)
Hsieh M.-H.
Abstract
Endoplasmic reticulum (ER) is an important intracellular organelle responsible for modifying and folding newly synthesized secretory and membrane proteins. Perturbations of ER homeostasis affect protein folding and cause ER stress. A key player in the cellular stress response is in the ER. The ER provides quality control system to refold and/or degrade misfolded proteins. The unfolded protein response, however, can trigger cell death if ER dysfunction is severe or prolonged. It is thought that the ER stress is associated with the pathogenesis of type 2 diabetes. Because the islet amyloid polypeptide in beta cells undergoes a change in tertiary structure followed by self-association and tissue deposition, which eventually causes beta cell dysfunction, type 2 diabetes is also defined as a conformational disease.
Subjects
Apoptosis; Chaperone; Conformational disease; Endoplasmic reticulum stress, ER stress; Islet amyloid polypeptide, IAPP; Unfolded protein response, UPR
SDGs
Other Subjects
amylin; membrane protein; protein kinase R; secretory protein; article; cell death; cell function; endoplasmic reticulum; homeostasis; human; hyperhomocysteinemia; non insulin dependent diabetes mellitus; nonhuman; pancreas islet beta cell; pancreas islet disease; pathogenesis; physiological stress; protein assembly; protein degradation; protein folding; protein metabolism; protein modification; protein tertiary structure; regulatory mechanism; tissue distribution
Type
journal article