Chemical Probes for Drug-Resistance Assessment by Binding Competition (RABC): Oseltamivir Susceptibility Evaluation
Journal
Angewandte Chemie - International Edition
Journal Volume
52
Journal Issue
1
Pages
366-370
Date Issued
2013
Author(s)
Cheng, T.-J.R. et al.
Abstract
The wizard of OS (resistance): The binding difference of neuraminidase inhibitors (zanamivir versus oseltamivir (OS)) was used to establish an assay to identify the influenza subtypes that are resistant to OS but still sensitive to zanamivir (see scheme). This assay used a zanamivirbiotin conjugate to determine the OS susceptibility of a wide range of influenza viruses and over 200 clinical isolates. © 2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
SDGs
Type
journal article