Auditory event-related potential of subjects with suspected pre-psychotic state and first-episode psychosis
Journal
Schizophrenia Research
Journal Volume
140
Journal Issue
43833
Pages
243-249
Date Issued
2012
Author(s)
Shan, J.-C.
Huang, W.-L.
Cheng, W.-C.
Jaw, F.-S.
Hwu, H.-G.
Abstract
Background: Recent schizophrenia research exploring the complicated pathogenesis of schizophrenia has focused on the subjects with at-risk mental states in order to exclude the influence of confounding factors. This study explores 3 sets of auditory-related event potentials in subjects with different risk levels of psychosis. Methods: Subjects were recruited from the SOPRES study in Taiwan. P50 and N100 using an auditory paired-click paradigm and duration MMN were assessed on 32 first-episode psychosis (FEP), 30 ultra-high risk (UHR), 37 E-BARS (early/broad at-risk mental states) participants and 56 controls. Results: MMN was correlated with neither P50 nor N100, whereas many parameters of the latter two were intercorrelated with each other. Compared to healthy controls, MMNs were significantly lower in all 3 clinical groups (E-BARS, UHR and FEP). A gradient of sensory-gating deficits, manifested by increased P50 ratios (S2/S1) and decreased N100 differences, across different levels of clinical severity was suggested by a linear trend. For the UHR subjects, P50 gating ratio, N100 gating ratio, N100 difference, and N100. S2 amplitude might be potential indicators to discriminate converters from non-converters. Conclusions: By including subjects with E-BARS, our results provide new insight regarding pre-attentive auditory event-related potential in subjects across different risk levels of psychotic disorders. Impaired deviance detection shown by MMNs already exists in people at a pre-psychotic state regardless of clinical severity, while sensory-gating deficits shown by P50/N100 varies depending on the risk levels in prodromal period. Further longitudinal research exploring the relationship between ERPs and subjects with a suspected pre-psychotic state is needed. ? 2012 Elsevier B.V.
SDGs
Other Subjects
neuroleptic agent; adult; age distribution; amplitude modulation; article; attention; controlled study; disease severity; drug effect; evoked auditory response; female; high risk population; human; latent period; major clinical study; male; mental health; priority journal; psychologic assessment; psychosis; risk assessment; sensory gating; sex difference; Acoustic Stimulation; Adolescent; Adult; Contingent Negative Variation; Electroencephalography; Evoked Potentials, Auditory; Female; Humans; Male; Psychoacoustics; Psychotic Disorders; Reaction Time; Sensory Gating; Taiwan; Young Adult
Type
journal article