The inhibitory effect on posterior capsular opacification by different intraocular lenses in a rabbit model
Date Issued
2012
Date
2012
Author(s)
Chang, Ya-Fei
Abstract
Posterior capsular opacification (PCO) is the most common long-term complication of modern cataract surgery both in human and dogs. Intraocular lenses (IOLs) have been introduced specifically to prevent PCO in humans. Biocompatibility and geometry are two major factors determined the inhibitory effect of IOLs. Different combinations of IOL designs and materials may result in different PCO grades. The relationship between PCO and canine IOLs is still unclear. The purpose of this study was to evaluate the inhibitory effect of currently available canine IOL- CLV12 (Cara TM Life, Inc.) in a rabbit model.
Six New Zealand white rabbits were divided into 3 groups, the aphakic, IOL-C and IOL-H. In aphkic group, capsular bags were kept in aphakic after receiving phacoemulsificaiton. In IOL-C and IOL-H groups, canine IOL CLV-12 and human IOL Akreos® Adapt (Bausch& Lomb) were implanted respectively. Clinical evaluation, gross examination, and histological analysis of PCO were performed in 8-week follow up period.
The results showed that clinical PCO scores increased gradually with time, but there was no statistical difference between groups. Under gross examination, pseudophakic groups (IOL-C and IOL-H) had less peripheral PCO formation than aphakic group, which indicate the inhibitory of IOLs. As for central (optic) areas of capsular bags, all groups remained clear. Histopathological evaluation confirmed the barrier effect of IOLs, and also noted that adhesion between anterior and posterior capsule were effective in preventing lens epithelium cells (LECs) migration, which results in low axial PCO grade of aphakic eyes. Clinical and gross PCO scores were moderately correlated.
In conclusion, this study confirms the peripheral PCO inhibitory effects of CLV-12. Central area of aphakic eyes can remain as clear as pseudophakic ones, which achieved by capsular adhesion.
Subjects
posterior capsular opacification
after cataract
intraocular lenses
rabbit model
dog
Type
thesis
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