Multiphoton and confocal imaging of precisely cut oral cancer tumor sections for personalized medicine
Journal
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Journal Volume
11244
Date Issued
2020
Author(s)
Chiang, Shu-Jen
Tseng, Po-Hang
Huang, Hsu-Cheng
Chen, Shih-Chi
Chen, Shean-Jen
Abstract
Traditionally, testing of therapeutic agents uses two-dimensional cell cultures which does not recapitulate the complex, three-dimensional architecture of tissues. In the case of cancer drug development, immunotherapy (IT) emerged as an effective treatment strategy for the patients who respond to therapy. However, the overall patient response rate for immunotherapy is around 25%. Therefore, there is a need to develop more effective drug testing platform for cancer patients. In this work, we develop three-dimensional tissue cultures of human oral cancer slices. We observed the growth dynamics of the tissue sections for up to 28 days. Their viability over extended periods suggest that the tissue sections may be used for personalized drug testing.
SDGs
Other Subjects
Diseases; Drug products; Patient treatment; Tissue culture; Tumors; Cancer patients; Confocal imaging; Human oral cancer; Multiphoton imaging; Oral cancer; Patient response; Therapeutic agents; Three-dimensional architecture; Personalized medicine
Publisher
SPIE
Type
conference paper