Nuclear expression of glioma-associated oncogene homolog 1 and nuclear factor-κb is associated with a poor prognosis of pancreatic cancer
Journal
Oncology (Switzerland)
Journal Volume
85
Journal Issue
2
Pages
86-94
Date Issued
2013
Abstract
Objective: We investigated the association of the hedgehog pathway with nuclear factor (NF)-κB and clinical outcomes in pancreatic cancer patients. Methods: We analyzed tissue samples for the expression of NF-κB (RelA/p65), sonic hedgehog (Shh) and glioma-associated oncogene homolog 1 (Gli1) by immunohistochemistry and investigated their expression in association with clinical outcomes. Results: Eighty-one patients with pancreatic cancer were investigated. Expression of Shh and nuclear expression of Gli1 and NF-κB were found in 63 of 66 (96%), 28 of 68 (41%) and 22 of 68 cases (32%), respectively. Nuclear Gli1 expression was closely associated with nuclear expression of NF-κB (p < 0.001). Patients with nuclear Gli1 had significantly worse prognoses than those without (median survival 7.9 vs. 13.9 months; p = 0.009). Similarly, patients with nuclear expression of NF-κB had shorter overall survival than those with negative or cytoplasmic expression of NF-κB (median survival 5.5 vs. 13.9 months; p < 0.001). Shh expression had no prognostic significance. In the multivariate analysis, NF-κB nuclear expression was closely associated with unfavorable overall survival (p = 0.02). Conclusion: Our results indicate that nuclear expression of Gli1 or NF-κB is a strong predictor of poor prognosis in pancreatic cancer. Additional investigation of the biologic significance of this association is warranted. ? 2013 S. Karger AG, Basel.
SDGs
Other Subjects
bevacizumab; CA 19-9 antigen; carcinoembryonic antigen; cetuximab; erlotinib; fluorouracil; gemcitabine; immunoglobulin enhancer binding protein; sonic hedgehog protein; transcription factor Gli1; sonic hedgehog protein; transcription factor RelA; adult; advanced cancer; aged; article; cancer prognosis; cancer radiotherapy; cancer surgery; cancer survival; cell nucleus; cytoplasm; disease association; distant metastasis; female; human; human tissue; immunohistochemistry; liver metastasis; major clinical study; male; medical record review; overall survival; pancreas cancer; priority journal; protein expression; retrospective study; treatment outcome; Article; cancer patient; cancer tissue; outcome assessment; pancreas cancer; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Nucleus; Deoxycytidine; Female; Hedgehog Proteins; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Pancreatic Neoplasms; Prognosis; Transcription Factor RelA; Transcription Factors; Treatment Outcome
Type
journal article