行政院國家科學委員會專題研究計畫成果報告:感覺及自主神經病變之診斷及其應用
Date Issued
2000
Date
2000
Author(s)
張楊全
DOI
892314B002144
Abstract
Pathological diagnosis of small-fiber neuropathy has traditionally depended on ultrastructural examinations of nerve biopsy specimens. To investigate the potential of epidermal nerve evaluation as a diagnostic approach, we performed 3-mm punch skin biopsies on healthy controls and patients with sensory neuropathy. Epidermal nerves were demonstrated by immunocytochemistry with the axonal marker, protein gene product 9.5. Patients with sensory neuropathy had both qualitative and quantitative features suggestive of cutaneous nerve degeneration. Degenerated dermal nerves exhibited a characteristic beaded appearance. Epiderrnal nerve density in the distal leg of healthy controls was 12.92±5.33 fibers/mm (mean±SD), and the value was markedly reduced in patients with sensory neuropathies, at 1.80 ¡Ó 3.16 fibers/mm (p <0.001). The results provide pathological criteria to interpret skin biopsies and also suggest that evaluation of epidermal innervation by skin biopsy is a feasible diagnostic approach with minimal invasiveness.
Subjects
Epidermal nerves
Skin biopsy
Small-fiber neuropathy
Skin innervation
Nerve degeneration
Publisher
臺北市:國立臺灣大學醫學院神經科
Type
journal article
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