Clinical predictors of self-limited urinalysis abnormality in childhood Henoch-Schönlein purpura nephritis
Journal
Acta Paediatrica, International Journal of Paediatrics
Journal Volume
95
Journal Issue
3
Pages
306-311
Date Issued
2006
Author(s)
Abstract
Background and aim: The majority of patients (85-95%) with Henoch-Sch?nlein purpura nephritis (HSPN) suffer from a prolonged course of urinalysis abnormality. We sought to identify favourable prognostic factors predicting a self-limited urinalysis abnormality within 1 y. Methods: Fifty-eight HSPN patients admitted to the University Hospital between 1990 and 2003 were retrospectively analysed. Detailed information on clinical and laboratory manifestations on admission and sequential follow-up clinics were recorded. The χ2 or Fisher's exact test were used for univariate analysis, and multiple logistic regression was used for multivariate analysis. Results: The study cohort included 31 boys and 27 girls, with a mean age of onset of 8.0±4.3 y and a median follow-up duration of 5.9 y (range 1 to 25). Of 58 patients, 39 (67.3%) had a self-limited urinalysis abnormality within 1 y. On multivariate analysis, onset age less than 9 (p =0.038), low-grade proteinuria (p =0.044) and interval between purpura onset and renal manifestations less than 2 wk (p =0.005) predicted self-resolved urinalysis abnormality within 1 y. With two or more predictive factors, the sensitivity for short-term course was 84.6%, the specificity was 73.7%, and the positive predictive value was 84.8%. Conclusion: A small number of variables were important for detecting a favourable short-term course of urinalysis abnormality. ? 2006 Taylor & Francis.
SDGs
Other Subjects
anaphylactoid purpura; article; child; clinical feature; controlled study; disease course; female; Fisher exact test; follow up; human; laboratory test; major clinical study; male; multivariate logistic regression analysis; nephritis; onset age; prediction; priority journal; prognosis; proteinuria; univariate analysis; urinalysis; Acute-Phase Proteins; Age Factors; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Immunoglobulin Isotypes; Kidney Function Tests; Male; Nephritis; Platelet Count; Predictive Value of Tests; Prognosis; Purpura, Schoenlein-Henoch; Retrospective Studies; Urinalysis; Urologic Diseases
Type
journal article