Steroids and Sesquiterpenoids from the Soft Corals Dendronephthya gigantea and Lemnalia cervicorni
Resource
Journal of Natural Products 67 (10): 1650-1653
Journal
Journal of Natural Products
Journal Volume
67
Journal Issue
10
Pages
1650-1653
Date Issued
2004
Date
2004
Author(s)
Abstract
One new cytotoxic steroid, dendronesterone A (1), two new steroids, dendronesterones B and C (2 and 3), and a known steroid (4) were isolated from the methylene chloride solubles of the Formosan soft coral Dendronephthya gigantea. Two cytotoxic ylangene-type sesquiterpenoids, lemnalol (5) and the new compound cervicol (6), as well as two ylangene-type sesquiterpenoids, isolemnalol (7) (a new compound) and 4-oxo-α-ylangene (8), were isolated from the methylene chloride solubles of the Formosan soft coral Lemnalia cervicorni. Their structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
Other Subjects
4 oxo alpha ylangene; cervicol; dendronesterone a; dendronesterone b; dendronesterone c; isolemnalol; lemnalol; sesquiterpenoid; steroid; unclassified drug; animal cell; animal tissue; antineoplastic activity; article; cancer cell; controlled study; coral; cytotoxicity; Dendronephthya gigantea; drug activity; drug isolation; drug structure; human; in vitro study; Lemnalia cervicorni; mouse; nonhuman; nuclear magnetic resonance spectroscopy; structure activity relation; technique; Animals; Anthozoa; Antineoplastic Agents; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Leukemia P388; Mice; Mice, Inbred DBA; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oceans and Seas; Sesquiterpenes; Steroids; Tumor Cells, Cultured; Alcyonacea; Animalia; Anthozoa; Dendronephthya; Dendronephthya gigantea; Lemnalia
Type
journal article
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