Application of Surface Modification on Biomedical Device in Drug Delivery and Resistance to Host Response
Date Issued
2011
Date
2011
Author(s)
Yi Chi Hsieh, Cindy
Abstract
Failure in turning on normal healing process has always been one of the major obstacles and complications in long-term artificial implants surgery. This can lead to possible foreign body reaction (FBR), where the implants may be encapsulated by fibrous collagen layer. In order to reduce host response, a facile polymer coating method was utilized in this study in reducing host response and foreign body reaction. In part 1 of this study, PMMA samples modified with p(PEGMA-co-AA)-g-Az copolymer successfully lowers RAW 264.7 cell adhesion and activation, with coating pH value of 6.5 and ratio of 9:1 PEGMA to acrylic acid copolymerization condition to exhibit lower macrophage adhesion. In vivo study also showed 13-15% reduction in encapsulation thickness with p(PEGMA-co-AA)-g-Az modified samples in compared to PMMA control. In part 2 of this study, the hydrogel successfully entrapped 30% (v/v) ketoprofen-PLGA micro-particles with low and sustained local release of anti-inflammatory drug. Though no difference in cell adhesion was observed with presence of ketoprofen, further in vivo analysis showed statistically lower encapsulated thickness with presence of ketoprofen in compared to p(PEGMA-co-AA)-g-Az without ketoprofen and PMMA control.
Subjects
biocompatibility,poly(ethylene) glycol
macrophage
foreign body reaction
drug release
Type
thesis
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