In vivo Oral Cancer Diagnosis with Optical Coherence Tomography
Date Issued
2005
Date
2005
Author(s)
Chen, Shu-Fan
DOI
en-US
Abstract
Recently, a lot of research groups around the world have focused their research on the biomedical applications of optical coherence tomography, covering from the diagnosis of human eyes and skin to gastrointestinal with endoscope. Among such research, the major efforts include optical system improvement, real-time imaging process, and probe design. Little research focused on a specific disease to build up image database for medical usage. However, except the diseases of the eyes. In our research, we develop an OCT system and suitable probes to diagnose oral cavity cancer, which has a high population rate than other developed countries. We will demonstrate the images of oral mucosa and compare the differences between the normal tissues with diseased ones.
In this study, to reach tissues at different location in a oral cavity, we develop three probes of the features of miniature, convenience, and fast-scanning. Besides, by choosing a superluminescent diode as the light source, designing a fiber-based system, and integrating the whole system on a damping handcart, we can move this OCT system easily to meet the clinical environment.
Before the application to oral cavity cancer, we use a human skin as the sample for test. From our human skin images, we can clearly distinguish the structures such as stratum corneum, epidermis, papilla, and dermis. The scanning depth of 0.5 mm can be reached.
In our OCT imaging on oral cavity tissues, we first scan normal tissues located at several different positions such as masticatory mucosa and lining mucosa. We can clearly distinguish the epithelium, lamina propria, and submucosa. The scanning depth of 0.9 mm can be reached. In clinical scanning, the oral cancer tissues on several patients have been imaged. From the comparison between the cancerous and normal tissues, we find that the backscattered intensities of diseased tissues are stranger. Also, the interface between epithelium and lamina propria is more unclear.
Subjects
光學同調斷層掃瞄
口腔癌
活體
干涉
醫學造影
Optical Coherence Tomography
oral cancer
in vivo
imaging
SDGs
Type
thesis
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