A Newly-designed Probe for Clinical Oral Cancer Diagnosis with Optical Coherence Tomography
Date Issued
2006
Date
2006
Author(s)
Lee, Hsiang-Chieh
DOI
en-US
Abstract
In this research, a fiber-based optical coherence tomography (OCT) system is built, which utilized the broadband SLD light source with the central wavelength at 1300 nm and the spectral width at 100 nm. In the OCT system, an optical phase delay line is implemented for the fast scanning requirement with the scanning frequency up to 250 Hz. The axial resolution of the OCT system is 8 microns. Its sensitivity is 80 dB. A compact rotation-type probe specially designed for the oral cavity scanning is fabricated. The lateral resolution of the system is 14 microns. With this hand-held probe, the in vivo scanning results of human skin are first obtained. In such scanning, three major layers, including stratum corneum, epidermis, and dermis, can be clearly identified. The penetration depth of human skin scanning images is 600~800 μm. The image size of human skin scanning of 1 mm x 1mm can be completed in less than one second.
To test the clinical application, in vivo scanning of oral mucosa was performed. In such scanning, two types of oral mucosa, including labial mucosa (lip) and specialized mucosa (the dorsal surface of tongue) are scanned. In the labial scanning images, three major layers, including epithelium, lamina propria, and submucosa, can be identified. The scanning depth of labial mucosa was 600~700 μm. In scanning the images of specialized mucosa, some glands inside the layer of lamina propria can be observed. This OCT system will be used for clinical diagnosis of oral cavity cancer at the National Taiwan University Hospital.
Subjects
光學同調斷層掃瞄
口腔癌
探頭
optical coherence tomography
oral cavity cancer
probe
SDGs
Type
thesis
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