Probing the tratis of epithelial-mesenchymal transition in a microfluidic device
Journal
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Journal Volume
1
Pages
145-147
Date Issued
2011
Author(s)
Abstract
The epithelial to mesenchymal transition (EMT) plays a crucial role during cancer invasion and metastasis [1, 2]. In this paper, we present a microfluidic device that can facilitate probing the traits of EMT in micrometer-scale environments. Furthermore, we show that epithelial cancer cells can grow to a tumor spheroid in the device, acquire properties of mesenchymal cells, and have an increased ability of migration, comparing with native cancer cells. The microfluidic device requires no external pumping systems yet being pipette-friendly in usage. Copyright ? (2011) by the Chemical and Biological Microsystems Society.
Subjects
EMT; Microfluidic; Pipette-friendly; Tumor spheroid
SDGs
Other Subjects
EMT; Epithelial cancer cells; Epithelial to Mesenchymal transitions; Epithelial-mesenchymal transition; Mesenchymal cells; Micro-fluidic devices; Pipette-friendly; Tumor spheroid; Microfluidics; Tumors; Fluidic devices
Type
conference paper