Nanodrug Combined with Physical Methods for Cancer Tumor Treatment in A Mouse Ear Model
Date Issued
2010
Date
2010
Author(s)
Shiu, Heng-Ruei
Abstract
Studies show that ultrasound (US) with microbubbles (MB) or hyperthermia (HT) could enhance the delivery of nanoparticles into tumor tissues. In this research, we used mouse ear tumor model to study the effectiveness of nanodrug on the tumor treatment with the enhancement of ultrasound/ microbubbles and/or hyperthermia, and observed the tumor growth with microscopy. The treatment procedure was arranged with four successive treatments every other day, and then followed the same four successive treatments after a week off.Experimental results showed that treatment enhancement can be observed for nanodrug injection followed by MB/US, or HT (43℃, 15 min),or MB/US/HT. The treatment set with MB/US/HT following nanodrug injection can even make the tumor disappear. The results of this study indicates that MB/US/HT following the injection of nanodrug is a very promising method for effective tumor treatment.
Subjects
ultrasound
microbubbles
hyperthermia
drug delivery
mouse ear tumor model
SDGs
Type
thesis
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