The association between maternal nonylphenol exposure and parity on neonatal birth weight: A cohort study in Taiwan
Journal
Chemosphere
Journal Volume
93
Journal Issue
6
Start Page
1145-1152
ISSN
0045-6535
Date Issued
2013-10
Author(s)
Chang, Chia-Huang
Chen, Mei-Lien
Tsai, Yen-An
Mao, I-Fang
Wang, Tzu-Hao
Hwang, Shiaw-Min
Chang, Yu-Jen
Tsai, Ming-Song
Abstract
Background: The aim of this study was to explore the association between NP exposure and parity and their effect on neonatal birth weight.
Methods: A cohort of pregnant women was established in a medical center in North Taiwan. Urinary NP concentration was determined by high-performance liquid chromatography coupled with fluorescent detection and adjusted using creatinine. A multivariable regression model was fit to determine the association between the maternal NP level in each trimester and neonatal birth weight. The odds ratios (ORs) of infant birth weight below the 10th, 25th, and 50th percentiles, comparing pregnant women with the different NP exposure levels, was estimated using a logistic regression.
Results: Of the 162 pregnant women in the study, 99 were multiparas and 63 were primiparas. After adjusting for other covariates, the NP level in the second trimester had a significant association with birth weight in the primiparas (β = -182.49 g, p value = 0.02). The OR of low infant birth weight, comparing pregnant women with different NP levels, was increased by decreasing the cutoff percentile for birth weight (OR = 1.18 for the 50th percentile, 2.12 for the 25th percentile, and 7.81 for the 10th percentile). The odds of primiparas with high NP level having a low neonatal birth weight increased to 3.87, 11.77, and 9.40 for the three different percentiles (p value < 0.05).
Conclusion: Maternal NP exposure level is associated with an increased risk of low neonatal weight. Primiparas are especially at risk, and the second trimester of pregnancy may be the critical stage of exposure.
Subjects
Birth weight
Nonylphenol
Pregnant woman
Primipara
Publisher
Elsevier BV
Type
journal article