The Global Analysis of Asymmetrically Expressed Genes in the Mammalian Brains
Date Issued
2004
Date
2004
Author(s)
Lee, Pei-Chih
DOI
en-US
Abstract
Brain asymmetry is thought to reflect evolutionary, genetical, developmental, experiential and pathological factors. Accumulating evidence suggests that the brain is asymmetrical in anatomical, functional and neurochemical aspects, and such asymmetry has been linked with several neurological diseases. With the use of gene profiling by microarray hybridization and two-dimension electrophoresis, we performed a global search for asymmetrically expressed genes in the mouse brain. Several candidate genes were found to be expressed asymmetrically within the left and right hippocampus. The transcript of one of these genes, Transthyretin (Ttr), exhibited sex-dependent asymmetry of distribution between the left and right ventricles in the male mice. This asymmetry appeared to be the result of uneven distribution of the choroid plexus cells, in which Ttr is synthesized within the brain. In most females, however, Ttr expression was more symmetrical in the lateral ventricles. In view of the known functions of Ttr in the transport of thyroid hormone and vitamin A, and its capacity of the sequestration of soluble β-amyloid, we speculate on a relationship between Ttr asymmetry and Alzheimer’s disease.
Subjects
不對稱
asymmetry
Ttr
Type
other
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