Effects of Hyperbaric Oxygenation Therapy on Lipopolysaccharide-Induced Systemic Inflammatory Response Syndrome Model in Cytokines Change and Protection of Hepatic Failure
Date Issued
2006
Date
2006
Author(s)
Chen, Hong-Ming
DOI
zh-TW
Abstract
The present study is designed to reveal the possible mechanism and the therapeutic potential for hyperbaric oxygen therapy (HBO) in the treatment of sepsis , also protection effect on liver during sepsis. Immediate HBO treatment ( 2 ATA , 75 min ) was applied to assess the survival rate of septic BALB/c mice induced by LPS within 84 hours period. The changes of plasma TNF-α and IL-10 after LPS challenge were measured. The pathological change of liver at 24 hours after LPS challenge treated with/without HBO treatment were also studied. The experimental results demonstrates that: (1) immediate HBO exposure after LPS challenge increases the survival rate of mice from 25% to 75%, (2) the plasma concentration of TNF-α after LPS challenge is reduced by immediate HBO treatment, (3) HBO treatment may protect liver from septic injury. In conclusion , HBO treatment exerts beneficial effects on sepsis induced by LPS in BALB/c mouse. The possible mechanism may be due to immunomodulation effect of HBO on immune system.
Subjects
內毒素
全身性發炎反應症候群
肝衰竭
HBO
LPS
SIRS
hepatic failure
Type
text
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