Bifunctional Cd2O3/C nanoshells for MR imaging and NIR therapeutic applications
Journal
Advanced Functional Materials
Journal Volume
19
Journal Issue
2
Pages
249-258
Date Issued
2009
Author(s)
Abstract
This paper reports dual function Gd2O3/C nanoshells for application in MR contrast images and NIR-triggered killing cancer cells. The nanoshells are prepared using biological gelatin particles as core templates through a two-step thermal treatment The surfaces of the nanoshells can be readily modified by poly(styrene-alt-maleic acid) (PSMA) polymer to improve their water-dispersible properties and increase their biocompatibility. The Gd2O3/C nanoshells show brightened images of kidney cortex and liver in mice, whereas the Gd2O3/C @ PSMA nanoshells show a darkened liver signal. The biodistribution is measured as a function of time and shows that the nanoshells circulate in the vessels and are cleared out gradually from organs. The graphite carbon coated on the Gd2O 3 nanoshells displays absorbance in the near-IR (NIR) region. A large extinction coefficient is obtained, indicating the potential of the nanoshells as photothermal agents. The Gd2O3/C @ PSMA nanoshells conjugated with anti-epithermal growth factor receptor antibodies are used for targeting and destroying A549 lung cancer cells by means of NIR-triggered killing capability. Both laser power density and material dose dependence are investigated to evaluate photothermolysis in cancer cells. ? 2009 WILEY-VCH Verlag GmbH & Co. KGaA.
Other Subjects
Biocompatibility; Gadolinium; Graphite; Heat treatment; Infrared devices; Laser surgery; Liver; Nanostructures; Probability density function; Styrene; Water treatment; Absorbance; Bifunctional; Bio distributions; Cancer cells; Dose dependences; Dual functions; Epithermal; Extinction co-efficient; Function of time; Graphite carbons; Growth factors; Laser power densities; Lung cancer cells; Mr imaging; Nanoshells; Photo thermals; Photothermolysis; Poly (styrene alt maleic acid); Therapeutic applications; Thermal treatments; Water-dispersible; Nanostructured materials
Type
journal article