Contemporary management of pediatric spinal tumors: a single institute's experience in Taiwan in the modern era
Journal
Journal of neuro-oncology
Journal Volume
146
Journal Issue
3
Pages
501
Date Issued
2020-02
Abstract
Introduction: Pediatric spinal tumors are unique pathologies treated by pediatric neurosurgeons. Special attention is required for the preservation of neural function and bony alignment. We reported our experience in the management of these challenging lesions.
Methods: A total of 75 pediatric patients with spinal tumors treated at the National Taiwan University Hospital from 1998 to 2018 were identified retrospectively. Clinical data, radiographic image, and pathological report were reviewed for analysis.
Results: There were 37 females and 38 males. The median age was 9 years. Thirty-eight tumors (50.6%) were extradural, 20 (26.7%) intradural extramedullary, and 17 (22.6%) intramedullary. The most common pathologies were glioma, ependymoma, and neuroblastoma. The rate of total and subtotal resection was 45.3% and 21.3%. Thirty-four patients (45.3%) required post-operative adjuvant therapy. Eight patients (10.6%) with spinal deformity had simultaneous tumor excision and spinal fusion surgery. Additional six (8%) patients had subsequent spinal fixation and fusion for deformity after primary tumor operation. Eighty-four percent of patients were ambulatory 3 years after operation. For patients with intradural extramedullary and intramedullary tumors, worse survival outcome was associated with tumor derived from CSF seeding and cranial involvement of spinal tumor, while poorer functional outcome was correlated with cranial involvement and adjuvant therapy with chemotherapy or radiotherapy.
Conclusions: Pediatric spinal tumor surgery carries low surgical morbidity and mortality under current standard of neurosurgical practice. Post-operative adjuvant therapy is required for nearly half of the cases. Spinal deformity requires special attention and sometimes surgical correction. Contemporary management of pediatric spinal tumors enables effective ablation of the lesion and delivers favorable outcome for the majority of patients.
Subjects
Children
Spinal cord tumor
Spinal surgery
Spinal tumor
SDGs
Other Subjects
adolescent; adult; ambulatory care; Article; brain surgery; cancer adjuvant therapy; cancer radiotherapy; cancer surgery; cancer survival; cerebrospinal fluid; child; clinical study; cohort analysis; ependymoma; female; glioma; health care management; human; infant; intracranial tumor; intradural extramedullary tumor; intradural intramedullary tumor; major clinical study; male; neuroblastoma; newborn; pathology; postoperative care; radiological procedures; retrospective study; spinal cord tumor; spine fusion; spine malformation; Taiwan; university hospital; disease management; Kaplan Meier method; pediatrics; preschool child; procedures; spine tumor; Adolescent; Child; Child, Preschool; Disease Management; Female; Humans; Infant; Infant, Newborn; Kaplan-Meier Estimate; Male; Pediatrics; Progression-Free Survival; Retrospective Studies; Spinal Neoplasms; Taiwan
Publisher
SPRINGER
Type
journal article