Effect of Product containing Pine Bark Extract on Lipid Metabolism in Hamsters
Date Issued
2006
Date
2006
Author(s)
Chung, Cheng-Pei
DOI
zh-TW
Abstract
The trade name of French marine pine bark extract is Pycnogenol ®（PYC）, and many researches have referred that PYC possesses some physiological activities, but that is poor on hypolipidemic. The aim of this study is to investigate the effect of French marine pine ( Pinus maritima ) bark extract on lipid metabolism, and from above to presume the mechanism of the hypolipidemic activity. In this experiment, 48 hamsters were divided into 6 groups according to their weight, and gave them the modified diet according to AIN-93M. The high-fat diet contained 5% lard and 0.2% cholesterol additionally, whereas the positive-control contained 4% β-sitosterol. The three experimental groups contained 0.2%, 0.4%, 0.8% ( low, medium, and high dose ) product powder rich of PYC, additionally. In the results, serum-TC ( total cholesterol ) was significantly decreased compared with high-fat group, but there were no differences between the three experimental groups, and serum-TG ( triglyceride ) was decreased in linear manner, but not significant in low dose group. The serum-LDL ( low density lipoprotein cholesterol ) was also significantly decreased in linear manner, but PYC did not influence the concentration of serum-HDL ( high density lipoprotein cholesterol ). In liver lipid, liver-TC was significantly decreased in high dose group, whereas liver-TG was decreased most significantly in low dose group, but the consistence percentage of liver-fatty acid was not influenced. On the effect of excreting lipid, feces-TC, feces-TG, and feces-bile acid were all decreased in dose dependent fit. Serum-TBARS was decreased significantly compared with high-fat group in low and medium dose group, but increased significantly in high dose group, and the serum-TBARS in three experimental groups were increasing in linear manner. Liver-TBARS in experimental groups decreased, and significant in high dose group. Also, the lag time of LDL-C oxidation was prolonged in experimental groups significantly, and the LDL-C was not completely oxidized in high dose group during detection time.
Subjects
脂質代謝
Pycnogenol®
倉鼠
lipid metabolism
hyperlipidemia
hamsters
SDGs
Type
thesis
File(s)![Thumbnail Image]()
Loading...
Name
ntu-95-R93641024-1.pdf
Size
23.53 KB
Format
Adobe PDF
Checksum
(MD5):54ce361d491ed31bc9b07ffdbc42db3a