Isolation and Structure Elucidation of Natural Products from Hincksia mitchellae(Harvey) P. C. Silva
Date Issued
2007
Date
2007
Author(s)
Chen, Jui-Che
DOI
zh-TW
Abstract
Crude extracts of Hincksia mitchellae (Harvey) Silva has been found to exhibit significant anticlotting activity and antiviral activity in our previous screening task. The major pigment in the extract, fucoxanthin was reported to exhibit anticancer activity against human prostate and leukemia cancer. Here we investigated the chemical constituents of H. mitchellae for their structures and possible activities. Components of fucoxanthin (1), and its derivatives, apo-9’-fucoxanthinone (2), grasshopper ketone (3), apo-13’-fucoxanthinone (4), apo-13’-fucoxanthinol (5), and trans-phytol (6), linoleic acid (7), phytyl acylesters, phytyl lenoleate (8), phytyl 9-octadecenoate (9), phytyl hexadecanoate (10), α-tocopherylquinone (11), fucosterol (12), adenosine (13), tryptophane (14), and uridine (15) were isolated and structure determined on the basis of spectroscopic analysis and their correlation with the published spectroscopic data. Among them, compound (5) was a new compound ever published in the papers. This is the first paper of natural products from Hincksia mitchellae. Some of the isolated components are known to be bioactive, such as fucoxanthin and its derivatives in anticarcinoma activities, phytyl esters in antiulcer activity, α-tocopherylquinone in cytotoxicity against P-388 and HT-29 cell and
fucosterol in cytotoxicity against P-388. However, none of the isolated components was tested for their bioactivities.
Subjects
天然物
褐藻
藻褐素
natural products
brown algae
fucoxanthin
SDGs
Type
other