Mathematical study of the effects of different intrahepatic cooling on thermal ablation zones
Journal
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Pages
6866-6869
Date Issued
2011
Author(s)
Abstract
Thermal ablation of a tumour in the liver with Radio Frequency energy can be accomplished by using a probe inserted into the tissue under the guidance of medical imaging. The extent of ablation can be significantly affected by heat loss due to the high blood perfusion in the liver, especially when the tumour is located close to large vessels. A mathematical model is thus presented here to investigate the heat sinking effects of large vessels, combining a 3D two-equation coupled bio-heat model and a 1D model of convective heat transport across the blood vessel surface. The model simulation is able to recover the experimentally observed different intrahepatic cooling on thermal ablation zones: hepatic veins showed a focal indentation whereas portal veins showed broad flattening of the ablation zones. Moreover, this study also illustrates that this shape derivation can largely be attributed to the temperature variations between the microvascular branches of portal vein as compared with hepatic vein. In contrast, different amount of surface heat convection on the vessel wall between these two types of veins, however, has a minor effect. ? 2011 IEEE.
Subjects
1-D models
Bio-heat
Blood perfusion
Convective heat
Heat sinking
Hepatic veins
Microvascular
Model simulation
Portal veins
Radio-frequency energy
Temperature variation
Thermal ablation
Two-equation
Vessel walls
Ablation
Blood
Blood vessels
Liver
Mathematical models
Medical imaging
Three dimensional
Tissue engineering
Tumors
Heat convection
article
body temperature
catheter ablation
cold
heat
human
induced hypothermia
liver
liver vein
methodology
pathology
perfusion
portal vein
radiofrequency radiation
temperature
theoretical model
thermal conductivity
Body Temperature
Catheter Ablation
Cold Temperature
Hepatic Veins
Hot Temperature
Humans
Hypothermia, Induced
Models, Theoretical
Perfusion
Portal Vein
Radio Waves
Temperature
Thermal Conductivity
SDGs
Type
conference paper