Breast cancer risk associated with genetic polymorphism of androgen receptor
Date Issued
2004-07-31
Date
2004-07-31
Author(s)
黃俊升
DOI
922314B002271
Abstract
Recent attention has brought focus both on genetic predisposition and
gene-environmental interaction as susceptibility factors to the development of breast
cancer. The ethnic discrepancies in cancer risk associated with various genotypes may
be explained in part by the racial difference in the distribution of frequencies of the
genotypic polymorphism. Taiwanese breast cancer is characterized by younger age at
tumor onset, which suggests that genetic predisposition may be more important in
Taiwanese breast cancers than in others. Androgen receptor can mediate breast tumor
growth and progression. The androgen-receptor gene AR contains a highly polymorphic CAG trinucleotide repeat in its first exon. Polymorphisms of the AR gene may be
susceptibility factors for breast cancer. We investigated the genotypes of CAG repeat in
312 cases of breast cancer in Taiwan and compared the results with those of healthy
controls in the literature. The frequency distributions of CAG-repeat lengths in the
shorter allele of the case and control were not different, while those in the long allele
were significantly different between the case and the control. Women of S/S genotype
carries the lowest breast cancer risk and women of L/L carries the highest risk (odds
ratio 7.4, 95%CI 3.3-16.5), while women of S/L genotype have breast cancer risk
in-between (odds ratio 16.17, 95%CI 7.0-37.3). Our findings suggest the genotype
polymorphism of androgen receptor may be a susceptibility factor to breast cancer in
Taiwanese women.
Subjects
Breast Cancer
genetic polymorphism
susceptibility
androgen receptor
SDGs
Publisher
臺北市：國立臺灣大學醫學院外科
Type
report
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