胃癌致癌機轉:以基因體和蛋白質體方式探討腫瘤發生和進展的生物標記及細胞路徑─胃癌致病機轉：建立生物檢體、細菌、和病人資料庫的核心單位(2/3)
Other Title
Gastric carcinogenesis: Core unit for biospecimen bank, bacterial bank and
the patient’s data bank (2/3)
the patient’s data bank (2/3)
Date Issued
2004
Date
2004
Author(s)
林肇堂
DOI
922314B002124
Abstract
Gastric cancer (GC) is one of the most common cancers in Taiwan. It
causes more than 2000 cancer deaths annually in this island. Little is known
about the mechanism of gastric carcinogenesis, although the diagnosis and
treatment of GC have been significantly improved in the recent decades.
Therefore, we try to conduct an integrated project for studying gastric
carcinogenesis through genomic and ptrotomic approaches. The major goals
of the integrated project are to evaluate the pathogenic factors involved in the
initiation and progression, to dissect the undermining mechanisms, and to
identify useful markers for this malignancy. The integrated project is
composed of 5 component projects. This is the 5th component project, which
will serve as the “core unit” supplying various biospecimens for the
investigation of all other component projects. We have previously established
a “core unit” for gastric cancer study in Veteran General Hospital (VGH) and
National Taiwan University Hospital (NTUH) since 1999. The core unit has
provided adequate biospecimens for various laboratory investigation
including SNP, CGH, microarray, laser capture microscopy, and
microsatellite analysis. In the new integrated project to be conducted, we will
extend previous model to collect more cases with detailed data and
biospecimens for various uses to component projects.
In the first two years of grant periods, we have enrolled nearly 200
cases with GC. Biospecimens including gastric tissues, peripheral blood
mononuclear cells (PBMCs), and serum were collected. Following previous
experience in the first year, different H. pylori strains from 38 cases with GC,
106 cases with duodenal ulcer, 42 cases with gastric ulcer, and 42 cases
with nonulcer dyspepsia were successfully cultured. All these specimens
were available for users of component projects. In the following third year
grant period, we will further collect adequate biospecimens with sufficient
pathologic claracteristics of each case together with clinico-demographic data. New laboratory findings with valuable clinical impact shall be anticipated after
all these collocations.
Subjects
Gastric cancer
Biospecimen
Core unit
SDGs
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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