Tobacco smoking, alcohol drinking, betel quid chewing, and the risk of head and neck cancer in an East Asian population
Journal
Head Neck
Journal Volume
41
Journal Issue
1
Date Issued
2019-01
Author(s)
Yuan-Chin Amy Lee
Shuang Li
Yuji Chen
Qian Li
Chien-Jen Chen
Wan-Lun Hsu
Cairong Zhu
Jian Pan
Hongbing Shen
Hongxia Ma
Lin Cai
Baochang He
Yu Wang
Xiaoyan Zhou
Qinghai Ji
Baosen Zhou
Wei Wu
Jie Ma
Paolo Boffetta
Zuo-Feng Zhang
Min Dai
Mia Hashibe
Abstract
The smoking prevalence among men in China is high, but the head and neck cancer incidence rates are low. This study's purpose was to investigate the impact of tobacco, betel quid, and alcohol on head and neck cancer risk in East Asia. A multicenter case-control study (921 patients with head and neck cancer and 806 controls) in East Asia was conducted. The odds ratio (OR) and 95% confidence interval (CI) were estimated using logistic regression. Head and neck cancer risks were elevated for tobacco (OR = 1.58), betel quid (OR = 8.23), and alcohol (OR = 2.29). The total attributable risk of tobacco and/or alcohol was 47.2%. Tobacco/alcohol appeared to account for a small proportion of head and neck cancer among women (attributable risk of 2.2%). Betel quid chewing alone accounted for 28.7% of head and neck cancer. Betel quid chewing is the strongest risk factor for oral cavity cancer in this Chinese population. Alcohol may play a larger role for head and neck cancer in this population than in European or U.S.
SDGs
Type
journal article