mafB在細胞激素調節上所扮演的角色
The role of mafB in cytokine regulation
Date Issued
2005
Date
2005
Author(s)
Lin, Chun-Kuo
DOI
en-US
Abstract
Cytokines have been demonstrated to determine the cell fate during T helper cell differentiation. Th1 and Th2 cells separately secrete Th1 cytokine, such as IFN-γ, and Th2 cytokines, such as IL-4, IL-5, IL-10 and IL-13, and thereby promote more naïve T helper cells to differentiate into Th1 or Th2 cells. c-Maf is an IL-4-specific transcription factor in T helper cells. Upon stimulation, c-Maf is highly upregulated in Th2 cells, and can induce significant IL-4 expression to promote Th2 cell differentiation. T helper cells deficient in c-Maf result in a spontaneous bias toward the Th1 phenotype, which favors Th1-mediated diseases, such as autoimmune diabetes. Here, we demonstrate that another Maf family protein, MafB, is expressed both in in vitro- and in vivo-passaged EL4 cells upon stimulation in vitro. Moreover, the expression of MafB is downregulated in Th1-skewed CD4+ T cells, whereas it is obviously upregulated in Th2-skewed CD4+ T cells after activation. In consistent with c-Maf, MafB can significantly transactivate the activity on IL-2, IL-4, IL-5, IL-10, IL-12 and IL-13 promoters, but not on IFN-γ promoter, according to our luciferase analysis. Furthermore, CD4+ T helper cells overexpressing mafB or c-maf, through retroviral transduction, also show higher expressions of IL-4, IL-5, IL-10 and IL-13. Since MafB shows similar effects to c-Maf on cytokine regulation, an overlapping role of MafB and c-Maf in Th2 cell differentiation is suggested. However, the role of MafB in cytokine regulation and Th2 cell differentiation needs more investigation.
Subjects
輔助型T細胞
介白素4
Th1
Th2
GATA3
c-maf
mafB
IL-4
SDGs
Type
other