大氣微粒對糖尿病大鼠心血管疾病之影響：機轉研究(1/2)
Date Issued
2005-07-31
Date
2005-07-31
Author(s)
DOI
932320B002067
Abstract
Recent epidemiologic studies
suggest that the effect of particulate air
pollution on the cardiopulmonary
system is a significant public health
concern. Subjects with existing
respiratory and cardiovascular disease
are though to be more susceptible to PM
exposures. Some researchers suggest
that diabetes is another sub-population at
risk for PM-associated cardiovascular
events. However, the biological
mechanism remains unclear. The goal of
this study is to use diabetic animal
model to examine the relationship
between PM exposure and diabetes.
We used strepotozotozocin–induced
rats as diabetic animal model. Rats were
exposed to PM2.5 collected from
Hsing-Chung, Taipei by a single
intratracheal instillation. The
pathophysiological markers were
examined after PM exposure, including
oxidative stress, endothelial dysfunction,
acute phase and proinflammatory
cytokine. The pulmonary inflammation
and injury were also measured after PM
exposure.
The results revealed a significant
lung inflammation after PM exposure.
An increased total cells and proportion
of neutrophils, protein and LDH activity
in bronchoalveolar lavage were
observed in both non-DM and DM rats,
however, diabetes did not modify the
level of lung inflammation. As
compared with non-DM rats, diabetic
rats demonstrated significantly higher
plasma 8-OHdG, IL-6 and ET-1, and
lower nitrate and nitrite. The PM effect
was significant in 8-OHdG, ET-1 and
nitrite and nitrate in diabetic rats as
compared with non-DM.
Our study found both PM and
diabetes contributed to increased
oxidative stress and decreased
endothelial function in common pathway.
Further studies are needed to clarify the
mechanism.
Subjects
particulate matters
diabetes
cardiovascular disease
SDGs
Publisher
臺北市：國立臺灣大學公共衛生學院職業醫學與工業衛生研究所
Type
report
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