Controlling morphology evolution of titanium oxide–gold nanourchin for photocatalytic degradation of dyes and photoinactivation of bacteria in the infected wound
Journal
Journal of Colloid and Interface Science
Journal Volume
598
Pages
260-273
Date Issued
2021
Author(s)
Abstract
We report a one-pot, room-temperature, morphology-controlled synthesis of titanium oxide (TiOx)–gold nanocomposites (TiOx–Au NCs) using HAuCl4 and TiCl3 as precursors, and catechin as reducing agent. TiOx–Au NCs have a range of morphologies from star-like to urchin-like shape depending on the concentration of TiCl3 in the reaction mixture. The urchin-shaped TiOx–Au NCs exhibited excellent photocatalytic activity toward dye degradation due to strong light absorption, plasmon-induced excitation, high conductivity of the gold, and reduced hole-electron pair recombination. TiOx–Au NCs have the advantage of a wide range of light absorption and surface plasmon absorption-mediated excitation due to their abundant gold spikes, which enabled the degradation of dyes over 97% in 60 min, using a xenon lamp as a light source. In addition, TiOx–Au NCs are highly efficient for the photoinactivation of Escherichia coli and methicillin-resistant Staphylococcus aureus (MRSA), and Candida albicans through the photodynamic generation of reactive oxygen species (ROS) and damage to the bacterial membrane. The catechin derivatives on the NCs effectively promoted curing MRSA infected wounds in rats through inducing collagen synthesis, migration of keratinocytes, and neovascularization. ? 2021 Elsevier Inc.
Subjects
Bacterial inactivation
Dye degradation
One-step synthesis
Plasmon-induced sensitization
Radicals
Biodegradation
Chlorine compounds
Dyes
Electric lamps
Escherichia coli
Flavonoids
Gold
Light absorption
Morphology
Phenols
Photocatalytic activity
Surface plasmons
Titanium oxides
Catechin derivatives
Excellent photocatalytic activities
Methicillin-resistant staphylococcus aureus
Morphology evolution
Morphology-controlled
Neo-vascularization
Photo catalytic degradation
Surface plasmon absorption
Gold compounds
catechin
collagen
gold nanoparticle
gold nanourchin
radical
reactive oxygen metabolite
titanium dioxide
unclassified drug
wound healing promoting agent
coloring agent
gold
metal nanoparticle
titanium
A-549 cell line
animal cell
animal experiment
animal model
antibacterial activity
Article
bacterial membrane
bacterium culture
biocompatibility
Candida albicans
cell migration
collagen synthesis
conductance
controlled study
degradation
excitation
HEK293T cell line
Hep-G2 cell line
human
human cell
in vivo study
keratinocyte
light
light absorption
male
methicillin resistant Staphylococcus aureus
methicillin resistant Staphylococcus aureus infection
mouse
neovascularization (pathology)
NIH 3T3 cell line
nonhuman
photocatalysis
priority journal
rat
surface plasmon resonance
wound healing
wound infection
animal
Animals
Coloring Agents
Metal Nanoparticles
Methicillin-Resistant Staphylococcus aureus
Rats
Titanium
SDGs
Type
journal article