Anti-lymphangiogenic diterpenes from the bark of Calocedrus macrolepis var. formosana
Journal
Journal of Food and Drug Analysis
Journal Volume
29
Journal Issue
4
Pages
606-621
Date Issued
2021-01-01
Author(s)
Hsieh, Chin Lin
Wu, Ho Cheng
Wang, Shih Wei
ANGELA YU-CHEN LIN
Hsiao, George
Cheng, Ming Jen
Hsieh, Wen Tsong
Kuo, Yueh Hsiung
Abstract
Eight new diterpenes, 6a,7b-dihydroxyferruginol (1), 6a,7a-dihydroxyferruginol (2), 6a-hydroxyhinokiol (3), 4a-hydroxy-7-oxo-18-norabieta-8,11,13-trien-4a-ol (4a), 15,16-dehydrosugiol (5), 7-methoxy-6,7-secoabieta-8,11,13-triene-6,12-diol (6), 7a-acetoxyabieta-8,12-diene-11,14-dione (7), 7a-butyloxyethyloxyabieta-8,12-diene-11,14-dione (8), along withfour known compounds, 6,7-dehydroferruginol (9), 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (10), 7a-11-dihydroxy-12-methoxy-8,11,13-abietatriene (11), and 11,14-dihydroxy-8,11,13-abietatrien-7-one (12) were successfully isolatedfrom the bark of Calocedrus macrolepis var. formosana. The structures of all isolates were elucidated by physical data(appearance, UV, IR, optical rotation) and spectroscopic data (1D, 2D NMR, and HREIMS). Compounds 9, 10, 11, and 12 showed promising growth-inhibitory effect on human lymphatic endothelial cells (LECs). Among these compounds, compound 10 exerted the most potent anti-lymphangiogenesis property by suppressing cell growth and tube formation of LECs. In conclusion, the results revealed the anti-lymphangiogenic potentials of Formosan C. macrolepis var. formosana.
Subjects
Anti-lymphangiogenesis | Calocedrus macrolepis var.formosana | Diterpenes
Publisher
Taiwan Food and Drug Administration
Type
journal article