Identification of B7-H1 and PD-1 expressing T cellsinfiltrated in human oral squamous cell carcinoma
Date Issued
2009
Date
2009
Author(s)
Ou, Yu-Chih
Abstract
Oral squamous cell carcinoma(OSCC) accounts for over 90% of the oral malignant neoplasms, ranks as the sixth major cause of cancer mortality rate in Taiwan and the incidence rate is raising. In addition to mutation of oncogene and gene toxicity, the cancer immune-editing is one of the important factors in human cancer currently.he regulatory T cell and high levels of expression of coinhibitory B7 molecules are the mediators of immunosuppression in tumor microenviriment. Therefore, we investigated the relationship of B7-H1 and regulatory T cells in human oral squamous cell carcinoma.The results indicate that, in TIL, proportion of distinct CD25+ Foxp3+ cells in the CD4+ subset (88.08%) were enriched relative to that found in PBMC (64.71 %) from OSCC patients(p= 0.001)and PBMC(73.78%) from healthy donorp=0.04).The linear correction analysis indicated that Foxp3+ and B7-H1+Foxp3+ Tregs were positively correlated in TIL(R=0.61) and CD4+ T cell(R=0.75). The PD-1the receptor of B7-H1) average expression on CD4+CD25-Foxp3- and CD4+CD25+oxp3- in TIL is five- or six-fold to PBMC , but it is only two fold in CD4+CD25+oxp3+ regulatory T cell. The linear analysis indicated that PD-1 average expression and proportion of B7-H1+Foxp3+ Tregs on CD4+T cell were positively correlated (R=0.60).Furthermore, we also observe the B7-H1+ Foxp3+Tregs and PD-1+ T cell in the immunohistochemistry. Therefore, B7-H1+Tregs and PD-1+ T cell infiltrated in tumor may play a immunoregulatory role in oral squamous cell carcinoma.
Subjects
B7-H1
regulatory T cells
oral squamous cell carcinoma
PD-1
SDGs
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