A 45-year experience of uveal melanoma in Taiwan: Verification of American Joint Committee on Cancer staging system and prognostic factors
Journal
Journal of the Formosan Medical Association
Journal Volume
120
Journal Issue
6
Pages
1361-1368
Date Issued
2021
Author(s)
Abstract
Background/Purpose: To verify the staging system of the American Joint Committee on Cancer (AJCC) 8th edition for uveal melanoma, and to propose the prognostic factors of uveal melanoma by a 45-year cohort study. Methods: We collected patients who underwent operation with pathological proof from 1973 to 2017. The demographic data including gender, age, laterality, metastatic pattern, and histopathology type were recorded. The predictability for survival and monotonicity of gradients of the AJCC 8th edition were evaluated. The prognostic factors for survival were analyzed by univariate and multivariate analysis. Results: A total of 72 patients were collected. The median age was 55 year-old (range 24–100). No specific gender predilection was revealed in our study. About 75.9% of metastases events happened in the first five-year of follow-up, and hepatic involvement was the most common. By the AJCC 8th edition, the distribution for stage I: II: III was 8 (11.1%), 37 (51.4%), and 27 (37.5%). The prognostic staging groups manifested fair predictability and monotonicity of gradients for survival outcome. The tumors with epithelioid cell type and ciliary body involvements had higher tumor-related mortality. Conclusion: The AJCC 8th edition prognostic staging groups for outcome prediction was validated. Periodic screening for metastases should be more frequent in the first five-year follow-up. The tumors with epithelioid cell pattern and ciliary body involvements were at risk of higher tumor-related mortality in Taiwanese patients. ? 2020 Formosan Medical Association
Subjects
Ciliary body; Melanoma; Neoplasm metastases; Uvea neoplasms
SDGs
Other Subjects
antineoplastic agent; adult; aged; Article; cancer diagnosis; cancer immunotherapy; cancer prognosis; cancer radiotherapy; cancer staging; cancer survival; ciliary body; cohort analysis; controlled study; demography; distant metastasis; echography; epithelioid histiocyte; eye enucleation; female; follow up; histopathology; human; liver function test; major clinical study; male; medical examination; multivariate analysis; positron emission tomography; retrospective study; sex difference; survival time; Taiwan; tumor volume; univariate analysis; uvea melanoma; whole body MRI; cancer staging; epidemiology; melanoma; middle aged; neoplasm; prognosis; United States; uvea tumor; Cohort Studies; Humans; Melanoma; Middle Aged; Neoplasm Staging; Neoplasms; Prognosis; Retrospective Studies; Taiwan; United States; Uveal Neoplasms
Publisher
Elsevier B.V.
Type
journal article