Filaggrin Polymorphism P478s, Ige Level, and Atopic Phenotypes
Resource
BRITISH JOURNAL OF DERMATOLOGY v.164 n.4 pp.791-796
Journal
BRITISH JOURNAL OF DERMATOLOGY
Journal Volume
v.164
Journal Issue
n.4
Pages
791-796
Date Issued
2011
Date
2011
Author(s)
WANG, I-JEN
LIN, TIEN-JEN
KUO, CHARNG-FONG
LIN, SHOEI-LOONG
LEE, YUNG-LING
Abstract
P>Background Whether environmental exposures may modulate the effect of the skin barrier gene on atopic dermatitis (AD ) remains to be elucidated. Objectives To determine whether filaggrin (FLG) variants can serve as a predictor for atopic disorders in Chinese individuals and if allergen exposures may modify the effect of FLG variants on AD by total IgE levels. Methods In total, 116 children aged 2-5 years with AD and 212 control subjects were analysed for the FLG variants using DNA sequencing. Multiple logistic regression models were performed to estimate the association among FLG polymorphisms and atopic phenotypes. Serum total IgE level, standing for the degree of allergen exposures, was later stratified to determine the effects of FLG polymorphisms on AD. Results A significant difference in genotype frequency was found among AD cases and controls in FLG P478S polymorphism. FLG P478S GG genotype significantly increased the risk of AD [odds ratio (OR) 4 center dot 60, 95% confidence interval (CI) 1 center dot 88-11 center dot 24]. In addition, among subjects with AD, GG genotypes also significantly increased the risk of developing asthma (OR 4 center dot 68, 95% CI 1 center dot 37-16 center dot 03). Further, a similar result was obtained for allergic rhinitis (OR 3 center dot 23, 95% CI 1 center dot 01-10 center dot 30 ). Interestingly, the P478S GG genotype was significantly related to AD (OR 5 center dot 67, 95% CI 1 center dot 93-16 center dot 60) in children with IgE level >= 100 kU L-1. However, the association was not evident when IgE level was< 100 kU L-1. Conclusions Our results suggest that the FLG P 478S polymorphism may confer susceptibility to the development of AD among Chinese individuals and may be modified by IgE levels.