A case-control study for estimating the population attributable proportion and association between type 2 diabetes mellitus and hepatocellular carcinoma at a viral hepatitis hyperendemic area
Date Issued
2007
Date
2007
Author(s)
Ko, Wei-Hsu
DOI
zh-TW
Abstract
Among causal models, a sufficient cause-component model differs from the other models in that it provides more information on causal mechanisms and defines biologic effects of several risk factors, particularly including strengths of association and their joint interaction effects. The advantage of looking at sufficient causes for the disease of interest is to give a clue to the mechanism of disease in question. We conducted a hospital-based case-control study with the inclusion of DM as a risk factor to elucidate the causal relationship leading to HCC after controlling for other major risk factors of HCC. In this hospital-based case control study, we corroborated the association between DM and HCC in Taiwan, where viral hepatitis B and C are hyperendemic. The estimated population attributable proportion indicated that diabetes accounted for 18.7% of HCC cases given 7% prevalence of diabetes. The independent contribution to the development of HCC cases in the absence of HBV and HCV infection was around 7.5%. In addition, we applied the method from the literature to calculate the adjusted population attributable proportion. We also developed a Bayesian acyclic graphic model to calculate the adjusted PAF and 95% confidence intervals.
Subjects
糖尿病
肝細胞癌
人口可歸因危險比例
相關性
病毒型肝炎
Diabetes mellitus
hepatocellular carcinoma
population attributable proportion
association
viral hepatitis
SDGs
Type
thesis
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