Toxicokineticstudies of perfluorinated chemicals in rodents
Date Issued
2012
Date
2012
Author(s)
Liu, Chien-Yu
Abstract
Perfluorinated chemicals (PFCs) include a group of man-made organic compounds, which are very stable and widely used in commercial and industrial applications. Recently, exposures to PFCs are concerned about their widely present in the animals and humans. They may cause potential adverse health effects to human such as hepatoxicity, nephrotoxicity, reproductive toxicity, and endocrines interference. At present, kinetic data is only available for single compound among a few of PFC. However, human have been exposed to a mixtures of PFCs in daily life. Therefore, the objective of this study is to explore the kinetics of PFCs mixtures in rodents to evaluate the potential interactions due to co-exposures to PFCs mixtures.
The male SD rats were classified into control, low exposure, and high exposure groups. Low exposure group were treated with a mixtures of 0.002 mg/kg PFBA、PFHxA and 0.05 mg/kg PFOA、PFNA、PFOS、PFDA and PFDoDA , and the high exposure group were treated with a mixtures of 0.0125 mg/kg PFBA、PFHxA and 1 mg/kg PFOA、PFNA、PFOS、PFDA and PFDoDA by the oral gavage. Subsequently urine and serum samples were collected and analyzed for these PFCs with a newly-developed on-line solid-phase extraction liquid chromatography tande, mass spectrometry (LC-MS/MS) method. These data were analyzed to construct their pharcokinetic models.
After data analysis, results show that PFBA can be eliminated during 24 hours from urine, and PFHxA is most rapidLy eliminated so that it was not detectable in serum or urine at 4 hours after treatment. At 2 hours after treatment, the PFOA and PFNA concentration in serum reached the maximum at 7000 ng/mL. PFNA was not well metabolized and excreted from urine and maintained the steady level in serum even at 81 days after treatment. PFOS、PFDA、PFDoDA couLd be determined at 1000-2000 ng/mL in serum at 2 hours after treatment, however, they couldn''t be detected at urine ,so they retained 500~1000 ng/mL in the serum.
These results suggest that the longer is the carbon chain of the PFCs; the longer is their half life; however, the half-lives of PFOA and PFNA may increase for co-exposure PFCs .The study showed that co-exposure PFCs at dose of 1 mg/kg would induce reproductive toxicity and liver toxicity, and we comprised the reference to find the addition reaction of toxicity.
Subjects
Perfluorinated chemicals
Half-Lives
Pharmacokinetics
SDGs
Type
thesis
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