Noninvasive tumor imaging with high-frequency ultrasound and microPET in small animals
Journal
Ultrasonic Imaging
Journal Volume
29
Journal Issue
4
Pages
201-212
Date Issued
2007
Author(s)
Abstract
In this study, we used a micro-ultrasound (microUS) system that we developed in-house as an alternative method for tumor growth calipers. In addition, microUS was combined with small-animal positron-emission tomography (microPET) for tumor metastatic assessment. MicroUS provides anatomical information that can be used for tumor volume measurements while microPET is a functional imaging method with positron-emitting radiophamaceuticals, such as 18F-labeled deoxyglucose, [18F]FDG. In this study, microUS and microPET were performed in a mouse tumor longitudinal study (2-8 weeks), both with 3D tumor segmentation and volume measurements. Compared with vernier calipers, microPET generally overestimated tumor volumes during weeks 2-4 due to its inadequate spatial resolution. During weeks 5-8, standard deviations of microPET results were large due to tumor hypoxia or necrosis. On the contrary, microUS tumor volume measurements were more reliable as they were less affected by these factors. Nonetheless, microUS is not able to provide functional information similar to that provided by microPET. Therefore, microUS and microPET are complementary to each other as microUS has superior spatial resolution and microPET provides functional information, such as hypoxia or necrosis in the progression of the tumor. With image registration and fusion, the combination can be a valuable tool for cancer research. Copyright 2007/2008 by Dynamedia, Inc. All rights of reproduction in any form reserved.
Subjects
High-frequency ultrasound; microPET; Three dimensional (3D) imaging; Tumor imaging; [18F]FDG
SDGs
Other Subjects
Animals; Cell death; Image resolution; Positron emission tomography; Positrons; Titration; Ultrasonics; Volume measurement; High frequency ultrasounds; Micro pets; Three dimensional (3-D) imaging; Tumor imaging; [^18F]FDG; Tumors; fluorodeoxyglucose f 18; animal experiment; animal model; article; cancer diagnosis; controlled study; echography; female; hypoxemia; longitudinal study; mouse; nonhuman; ovary carcinoma; positron emission tomography; reliability; tumor necrosis; tumor volume
Type
journal article