Axonal translation of β-catenin regulates synaptic vesicle dynamics
Journal
Journal of Neuroscience
Journal Volume
33
Journal Issue
13
Pages
5584-5589
Date Issued
2013
Author(s)
Taylor, A.M.
Wu, J.
HWAN-CHING TAI
Schuman, E.M.
Abstract
Many presynaptic transcripts have been observed in axons, yet their role in synapse development remains unknown. Using visually and pharmacologically isolated presynaptic terminals from dissociated rat hippocampal neurons, we found that ribosomes and β-catenin mRNA preferentially localize to recently formed boutons. Locally translated β-catenin accumulates at presynaptic terminals, where it regulates synaptic vesicle release dynamics. Thus, local translation of β-catenin is a newly described mechanism for axons to independently functionalize nerve terminals at great distances from cellular somata.
Type
journal article