Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease
Journal
Annals of Neurology
Journal Volume
64
Journal Issue
1
Pages
88-92
Date Issued
2008
Author(s)
Ross O.A
Wu Y.-R
Lee M.-C
Funayama M
Chen M.-L
Soto A.I
Mata I.F
Lee-Chen G.-J
Chiung M.C
Tang M
Zhao Y
Hattori N
Farrer M.J
Tan E.-K
Abstract
Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LKRK2 variants in sporadic Parkinson's disease. ? 2008 American Neurological Association. Published by Wiley-Liss, Inc., through Wiley Subscription Services.
SDGs
Other Subjects
leucine rich repeat kinase 2; adult; article; Chinese; controlled study; genetic risk; genetic variability; haplotype; human; major clinical study; Parkinson disease; priority journal; risk factor; Singapore; Taiwan; Asian Continental Ancestry Group; DNA Mutational Analysis; Female; Founder Effect; Gene Frequency; Genetic Markers; Genetic Predisposition to Disease; Genetic Screening; Genotype; Humans; Male; Middle Aged; Mutation; Parkinson Disease; Polymorphism, Genetic; Protein-Serine-Threonine Kinases; Singapore; Taiwan
Type
journal article