骨髓移植病人第八型人類泡疹病毒感染之研究
Date Issued
2000
Date
2000
Author(s)
李慶雲
DOI
892314B002041
Abstract
HHVS ia the newest member of human herpesviruses. Accumulative data indicates that a proportion of healthy adults is infected with HHV8. The prevalence could be as high as 50% in some countries. We have finished a seroprevalence study of HHV8 infection in Taiwanese adults and our data indicated that 15-20% of Taiwanesc arc infected with HHV8. Up to now, a variety of malignancies has been linked to HHV8. However, the clinical illness caused by HHVS is almost unknown to us. This study is aimed to understand HHVX infection or reactivation in adults and Dhildren undergoing bone marrow transplantation (BMT). We will prospectively study 50 BMT patients; their blood samples will be collected every week and their clinical data will be recorded. l-IHV8 IgG and 1gM antibodies in serum samples will be measured every week. Polymerase chain reaction (PCR) will be used to detect IHrIV8 genomc in peripheral blood mononuclear cells and 3cra. We expect to delineate the frequency of HHV8 infection or reactivation during the course of bone marrow transplantation. The timing, clinical manifestation and outcome of HHV8 infection in BMT patients can be Icamed. In the second half of this two-year project, quantitative PCR will be leveloped to more accurately monitor the activity of HHV8 and see whether this is a valuable Jiagnostic tool.
Subjects
HHV8
bone marrow transplantation
reactivation
SDGs
Publisher
臺北市：國立臺灣大學醫學院小兒科
Type
report
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